by Ramez Naam (2013). An eminently readable debut SF novel with a fertile imagination in which the confluence of nano- and neuro-science with brain-machine interfaces opens the way to manipulate your brain with software that you program in your mind. This is the post-human future. Of course, other protagonists can also hack that software and thereby control you. The novel takes place in 2040 in an America in which the surveillance state has taken hold and tries to prevent such trans-human technology – in the form of the drug Nexus-5 of the title – to dissipate into the general population (reserving it for its elite warriors). But other nation states and actors intervene. Violent, fast-paced, with believable characters and a storyline the novel offers one realistic future in which conflict arises between regular folks and the enhanced one. As a neuroscientist, west-coast techno-geek and libertarian, I do believe that the merging of our brains with our information technology is inevitable, for better or worse. It is not the business of the future to be predictable. Naam’s style is somewhere between Crichton’s Terminal Man and Gibson’s cyberpunk novels.